5 Key Takeaways

• 1

  The College of American Pathologists updated HPV testing guidelines for head and neck carcinomas, expanding on 2018 recommendations.

• 2

  The new guidelines include seven strong recommendations, four conditional recommendations, and five good practice statements.

• 3

  Routine HPV testing is recommended for sinonasal squamous cell carcinoma due to its association with a more favorable prognosis.

• 4

  For fine-needle aspiration specimens, HPV-specific testing is emphasized over p16 immunohistochemistry due to reliability concerns.

• 5

  The guidelines advise against routine repeat HPV testing for recurrent or metastatic disease if primary tumor HR-HPV status is known.