5 Key Takeaways

• 1

  A study in RMD Open examined complement system activation in relation to radiographic progression in axial spondyloarthritis patients.

• 2

  Serum samples from 96 patients were analyzed for complement activation and protein levels before and after TNFi therapy.

• 3

  Elevated baseline levels of C3dg, MASP-1, and decreased MASP-3 were linked to new bone formation after 2 years.

• 4

  At follow-up, elevated levels of C3dg and L-ficolin were observed in patients with new bone formation.

• 5

  The study concluded that complement activation markers predict new bone formation in axSpA patients despite TNFi therapy.