In the phase 3 OPTIMA trial, the 10-mg/kg and 3-mg/kg doses reduced new heterotopic ossification lesions by 90% and 94%, respectively, compared with placebo at 56 weeks.
A case report highlighted extensive intratendinous urate deposition and bilateral Achilles tendon rupture, raising awareness of tendon complications in advanced gout.
Joint tenderness showed broader associations with concurrent ultrasound abnormalities than patient-reported pain among anti-cyclic citrullinated peptide–positive patients without clinical arthritis.
In a single-center retrospective study, an internally validated model using radiologist-assessed imaging features and clinical data showed moderate discrimination of arthroscopic meniscal repairability.