5 Key Takeaways

• 1

  A study identified mechanisms linking dietary tryptophan breakdown to arthritis development, published by Seymour et al in The Journal of Clinical Investigation.

• 2

  Research utilized a mouse model of collagen-induced arthritis to explore alterations in tryptophan metabolism related to arthritis.

• 3

  Indole supplementation in low-tryptophan diet mice increased inflammatory cytokines and autoreactive T cells, while reducing regulatory T cells.

• 4

  Interleukin-23 neutralization decreased disease severity in mice with collagen-induced arthritis and indole supplementation.

• 5

  Exposure of human colonic lymphocytes to indole increased expression of genes linked to interleukin-17 signaling and plasma cell activation.