The use of cannabis may be linked to a higher risk of major adverse cardiovascular events, according to recent findings reported by Jeffers et al in the Journal of the American Heart Association. In a recent population-based, cross-sectional study, investigators used the 2016 to 2020 Behavioral Risk Factor Surveillance Survey to examine the outcomes of over 434,000 individuals residing in 27 U.S. states and 2 territories. They analyzed the number of days of cannabis use within the past 30 days and self-reported major adverse cardiovascular events—including myocardial infarction, stroke, and coronary artery disease—among individuals aged 18 to 74 years in the general population, never–tobacco smokers, as well as men younger than 55 and women younger than 65 at risk of premature cardiovascular disease. Among all participants, 4.0% used cannabis daily and 7.1% used cannabis nondaily. Daily cannabis use was associated with an increased risk of myocardial infarction (adjusted odds ratio [OR] = 1.25, 95% confidence interval [CI] = 1.07–1.46), stroke (adjusted OR = 1.42, 95% CI = 1.20–1.68), coronary artery disease (adjusted OR = 1.16, 0.98–1.38), and a composite of all three adverse outcomes (adjusted OR = 1.28, 95% CI = 1.13–1.44). Among never–tobacco smokers, daily cannabis use was correlated with a heightened risk of myocardial infarction (adjusted OR = 1.49, 95% CI = 1.03–2.15), stroke (adjusted OR = 2.16, 95% CI = 1.43–3.25), and a composite of all three adverse outcomes (adjusted OR = 1.77, 95% CI = 1.31–2.40). Risks were similar among the men and women at risk of developing premature cardiovascular disease. The investigators encouraged physicians to assess and communicate the cardiovascular risks of cannabis use. In a companion press release from the American Heart Association reporting on the findings, the study authors concluded: “Our study shows that smoking cannabis has significant cardiovascular risks, just like smoking tobacco. This is particularly important because cannabis use is increasing, and conventional tobacco use is decreasing.”